Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | POLQ | O75417 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.41 |
| ▸ | LCK | P06239 | 7/20 | 0.41 |
| ▸ | KDR | P35968 | 7/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 6/20 | 0.39 |
| ▸ | TEK | Q02763 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5491447 | 0.94 | POLQ (0.47) | POLQCSNK2A1ALOX15HTTMAPK14 | |
| SCHEMBL5495516 | 0.81 | GRIK1 (0.48) | POLQMAPK14LCKKDRCSF1R | |
| SCHEMBL14692057 | 0.79 | HTT (0.61) | CSNK2A1ALOX15HTTLCKCYP19A1 | |
| SCHEMBL17653046 | 0.77 | LCK (0.48) | ALOX15HTTMAPK14LCKKDR | |
| SCHEMBL5490221 | 0.77 | MAPK14 (0.50) | MAPK14LCKKDRCSF1RCYP19A1 | |
| SCHEMBL5494888 | 0.76 | LCK (0.60) | MAPK14LCKKDRFGFR4JAK3 | |
| SCHEMBL17653016 | 0.75 | LCK (0.44) | ALOX15HTTMAPK14LCKKDR | |
| SCHEMBL11949445 | 0.73 | ALOX15 (0.54) | MMP9POLQALOX15HTTCYP19A1 | |
| SCHEMBL30507829 | 0.71 | CSNK2A1 (0.59) | CSNK2A1ALOX15HTTLCKCYP19A1 | |
| SCHEMBL18614408 | 0.71 | CSNK2A1 (0.59) | CSNK2A1ALOX15HTTLCKCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC. (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006039718-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2006-04-13 | — | — | WO | disclosed |