Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.52 |
| ▸ | SLC22A12 | Q96S37 | 8/20 | 0.45 |
| ▸ | APOB | P04114 | 1/20 | 0.39 |
| ▸ | MTTP | P55157 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3851046 | 0.90 | MTNR1A (0.48) | MTNR1AMTNR1BSLC22A12APOBMTTP | |
| SCHEMBL3850247 | 0.74 | MTNR1A (0.46) | MTNR1AMTNR1B | |
| SCHEMBL3847526 | 0.72 | MTNR1A (0.50) | MTNR1AMTNR1B | |
| SCHEMBL1970411 | 0.70 | MTNR1A (1.00) | MTNR1AMTNR1B | |
| SCHEMBL1970413 | 0.70 | MTNR1A (1.00) | MTNR1AMTNR1B | |
| SCHEMBL13843837 | 0.70 | MTNR1A (0.39) | MTNR1AMTNR1BSLC22A12 | |
| SCHEMBL13843860 | 0.68 | PPARD (0.41) | MTNR1AMTNR1BPPARDPPARA | |
| SCHEMBL3858044 | 0.68 | MTNR1A (0.60) | MTNR1AMTNR1B | |
| SCHEMBL3973524 | 0.67 | MTNR1A (0.51) | MTNR1AMTNR1B | |
| SCHEMBL13843864 | 0.67 | EPHX2 (0.51) | PPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745016-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED TETRALIN AND SUBSTITUTED INDANE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005105737-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED TETRALIN AND SUBSTITUTED INDANE DERIVATIVES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-11-10 | — | — | WO | disclosed |