Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2783377 | 0.97 | DRD2 (0.54) | DRD2SLC6A4HRH3HTR1DHTR2A | |
| SCHEMBL2782294 | 0.94 | DRD2 (0.41) | DRD2SLC6A4HRH3DRD3HTR6 | |
| SCHEMBL2802234 | 0.81 | DRD2 (0.54) | DRD2SLC6A4HRH3HTR1DHTR2A | |
| SCHEMBL3766504 | 0.81 | DRD2 (0.59) | DRD2SLC6A4DRD3HTR6 | |
| SCHEMBL3761273 | 0.81 | DRD2 (0.59) | DRD2SLC6A4 | |
| SCHEMBL2781142 | 0.81 | DRD2 (0.39) | DRD2DRD3 | |
| SCHEMBL3772725 | 0.80 | DRD2 (0.57) | DRD2SLC6A4DRD3 | |
| SCHEMBL2782469 | 0.80 | DRD2 (0.57) | DRD2SLC6A4DRD3HTR6 | |
| SCHEMBL2783861 | 0.80 | DRD2 (0.57) | DRD2SLC6A4DRD3HTR6 | |
| SCHEMBL2783366 | 0.79 | DRD2 (0.41) | DRD2SLC6A4HRH3HTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773772-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-18 | — | — | EP | claimed |
| WO-2005121087-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | claimed |