SCHEMBL5497429

SCHEMBL5497429

O=C(O)C=Cn1cccc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.40
TP53 P04637 1/20 0.40
EGLN1 Q9GZT9 1/20 0.40
EGLN3 Q9H6Z9 1/20 0.40
HCAR2 Q8TDS4 5/20 0.36
HDAC3 O15379 1/20 0.36
TNKS O95271 1/20 0.36
HDAC4 P56524 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC7 Q8WUI4 1/20 0.36
HDAC2 Q92769 1/20 0.36
HDAC10 Q969S8 1/20 0.36
HDAC11 Q96DB2 1/20 0.36
HDAC8 Q9BY41 1/20 0.36
TNKS2 Q9H2K2 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
HDAC9 Q9UKV0 1/20 0.36
HDAC5 Q9UQL6 1/20 0.36
LPAR2 Q9HBW0 3/20 0.33
LPAR1 Q92633 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29212172 1.00 TSHR (0.40) TSHRTP53EGLN1EGLN3HCAR2
SCHEMBL31332676 1.00 TSHR (0.40) TSHRTP53EGLN1EGLN3HCAR2
SCHEMBL16587943 0.77 GLA (0.37) ALDH1A1KDM4EMAPT
Fumaric Acid SCHEMBL1449922 0.75 TSHR (0.43) TSHRTP53EGLN1EGLN3HCAR2
Maleic Acid SCHEMBL8132205 0.75 TSHR (0.43) TSHRTP53EGLN1EGLN3HCAR2
SCHEMBL15148226 0.72 MEN1 (0.30) TSHRALDH1A1
SCHEMBL6343791 0.70 TBXAS1 (0.44) EGLN3ALDH1A1TBXAS1
Maleic Acid SCHEMBL27583410 0.69 TSHR (0.82) TSHRTP53EGLN1EGLN3HCAR2
SCHEMBL1797068 0.69
SCHEMBL28075987 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10167501-B2 Methods and apparatus for quantification of nucleic acid amplification by monitoring impedances AUCKLAND UNISERVICES LIMITED (NZ) 2019-01-01 US claimed
US-20160046977-A1 Methods and Apparatus for Amplifying Nucleic Acids AUCKLAND UNISERVICES LIMITED (NZ) 2016-02-18 US claimed
EP-0688210-B1 USE OF CARNOSINE IN COMBINATION WITH UROCANIC ACID FOR TREATMENT OF PHOTODERMATOSES BEIERSDORF AG (DE) 2004-02-25 EP claimed
US-10167501-B2 Methods and apparatus for quantification of nucleic acid amplification by monitoring impedances AUCKLAND UNISERVICES LIMITED (NZ) 2019-01-01 US disclosed
US-20160046977-A1 Methods and Apparatus for Amplifying Nucleic Acids AUCKLAND UNISERVICES LIMITED (NZ) 2016-02-18 US disclosed
EP-1399577-B1 METHOD FOR PRODUCING L-AMINO ACIDS SHOWA DENKO KK (JP) 2007-02-07 EP disclosed
US-20040248118-A1 Method for producing l-amino acids SHOWA DENKO K.K. (JP) 2004-12-09 US disclosed
EP-1399577-A1 METHOD FOR PRODUCING L-AMINO ACIDS Showa Denko K.K. (JP) 2004-03-24 EP disclosed
WO-2003000915-A1 METHOD FOR PRODUCING L-AMINO ACIDS SHOWA DENKO K.K. (JP) 2003-01-03 WO disclosed
US-5723482-A CARNOSINE OR DERIVATIVE, UROCANIC ACID OR DERIVATIVE BEIERSDORF AG (DE) 1998-03-03 US disclosed
US-5039684-A Absorption when administered orally VALEAS S. P. A. (IT) 1991-08-13 US disclosed
EP-0384450-A1 Tetrazole amide derivatives of heterocyclic alkenyl acids and their use as antiallergic substances VALEAS S.p.A. INDUSTRIA CHIMICA E FARMACEUTICA (IT) 1990-08-29 EP disclosed