Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.30 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.30 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.30 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1774552 | 1.00 | SMN1; SMN2 (0.50) | SMN1; SMN2MEN1KMT2ACYP1A2ALOX15 | |
| SCHEMBL7283594 | 1.00 | SMN1; SMN2 (0.50) | SMN1; SMN2MEN1KMT2ACYP1A2ALOX15 | |
| SCHEMBL7435955 | 1.00 | SMN1; SMN2 (0.50) | SMN1; SMN2MEN1KMT2ACYP1A2ALOX15 | |
| SCHEMBL2905696 | 0.98 | ALOX15 (0.47) | SMN1; SMN2MEN1KMT2ACYP1A2ALOX15 | |
| SCHEMBL1775038 | 0.91 | — | — | |
| SCHEMBL1521786 | 0.83 | DPP7 (0.49) | SMN1; SMN2MEN1KMT2ACYP1A2ALDH1A1 | |
| SCHEMBL1521224 | 0.83 | DPP7 (0.49) | SMN1; SMN2MEN1KMT2ACYP1A2ALDH1A1 | |
| SCHEMBL2906945 | 0.82 | — | — | |
| SCHEMBL3069140 | 0.82 | SMN1; SMN2 (0.67) | SMN1; SMN2MEN1KMT2ACYP1A2ALOX15 | |
| SCHEMBL1923256 | 0.82 | SMN1; SMN2 (0.67) | SMN1; SMN2MEN1KMT2ACYP1A2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070141074-A1 | Agents for the inhibition of virus replication through regulation of protein folding | VIROLOGIK GMBH (DE) | 2007-06-21 | — | — | US | disclosed |
| US-5985824-A | Methods and compositions for treating cystic fibrosis | GENZYME CORPORATION (US) | 1999-11-16 | — | — | US | disclosed |
| WO-1998037878-A9 | METHODS AND COMPOSITIONS FOR TREATING CYSTIC FIBROSIS | — | 1999-02-11 | — | — | WO | disclosed |
| US-5834421-A | Methods and compositions for treating cystic fibrosis | GENZYME CORPORATION (US) | 1998-11-10 | — | — | US | disclosed |
| WO-1998037878-A1 | METHODS AND COMPOSITIONS FOR TREATING CYSTIC FIBROSIS | GENZYME CORPORATION (US) | 1998-09-03 | — | — | WO | disclosed |
| US-5401722-A | Peptide analogues | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-03-28 | — | — | US | disclosed |
| US-5378691-A | Amino acid derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-01-03 | — | — | US | disclosed |
| US-5328916-A | Renin inhibitors, hypotensive agents | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1994-07-12 | — | — | US | disclosed |
| US-5147857-A | Enzyme inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1992-09-15 | — | — | US | disclosed |
| EP-0501280-A2 | Renin-inhibiting peptide analogues | MERCK PATENT GmbH (DE) | 1992-09-02 | — | — | EP | disclosed |
| EP-0446485-A2 | Peptide analogues with renininhibiting activity | MERCK PATENT GmbH (DE) | 1991-09-18 | — | — | EP | disclosed |
| EP-0446751-A1 | Glycolic acid derivatives | MERCK PATENT GmbH (DE) | 1991-09-18 | — | — | EP | disclosed |
| EP-0418696-A2 | Derivatives of aminoacids | MERCK PATENT GmbH (DE) | 1991-03-27 | — | — | EP | disclosed |
| US-4956504-A | IMMUNOMODULATORS, ANTIBIOTICS | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1990-09-11 | — | — | US | disclosed |
| CN-1037155-A | Amino acid derivative | MERCK PATENT GMBH (DE) | 1989-11-15 | — | — | CN | disclosed |
| EP-0339483-A2 | Renin inhbiting amino-acid derivatives | MERCK PATENT GmbH (DE) | 1989-11-02 | — | — | EP | disclosed |
| EP-0337334-A2 | Renin-inhibiting amino acid derivatives | MERCK PATENT GmbH (DE) | 1989-10-18 | — | — | EP | disclosed |
| EP-0105193-B1 | SPERGUALIN-RELATED COMPOUNDS, PROCESSES FOR THE PREPARATION THEREOF AND THEIR USE AS MEDICAMENTS | MICROBIAL CHEMISTRY RESEARCH FOUNDATION (JP) | 1988-08-24 | — | — | EP | disclosed |
| EP-0241797-A2 | Novel spergualin-related compounds and process for producing the same | MICROBIAL CHEMISTRY RESEARCH FOUNDATION (JP) | 1987-10-21 | — | — | EP | disclosed |
| EP-0105193-A2 | Spergualin-related compounds, processes for the preparation thereof and their use as medicaments | MICROBIAL CHEMISTRY RESEARCH FOUNDATION (JP) | 1984-04-11 | — | — | EP | disclosed |