Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 2/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3862734 | 0.87 | KCNN4 (0.50) | KCNN4KIF11GRIN1GRIN2AGRIN2D | |
| SCHEMBL3862881 | 0.87 | KCNN4 (0.50) | KCNN4KIF11GRIN1GRIN2AGRIN2D | |
| SCHEMBL3666885 | 0.83 | KCNN4 (0.50) | KCNN4KIF11GRIN1GRIN2AGRIN2D | |
| SCHEMBL4484584 | 0.83 | KCNN4 (0.50) | KCNN4KIF11GRIN1GRIN2AGRIN2D | |
| SCHEMBL3307096 | 0.83 | KCNN4 (0.50) | KCNN4KIF11GRIN1GRIN2AGRIN2D | |
| SCHEMBL3853261 | 0.83 | KCNN4 (0.50) | KCNN4KIF11GRIN1GRIN2AGRIN2D | |
| SCHEMBL6565005 | 0.81 | KCNN4 (0.47) | KCNN4KIF11GRIN1GRIN2AGRIN2D | |
| SCHEMBL3852207 | 0.81 | KCNN4 (0.47) | KCNN4KIF11GRIN1GRIN2AGRIN2D | |
| SCHEMBL3854524 | 0.81 | KCNN4 (0.47) | KCNN4KIF11GRIN1GRIN2AGRIN2D | |
| SCHEMBL3853041 | 0.78 | KCNN4 (0.47) | KCNN4KIF11GRIN1GRIN2AGRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1529047-B1 | NEW PURINE DERIVATIVES | CYCLACEL LTD (GB) | 2007-02-21 | — | — | EP | disclosed |