Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 10/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | PHGDH | O43175 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5493014 | 0.91 | CRHR1 (0.51) | CRHR1PHGDHCYP1A2CYP2C19 | |
| SCHEMBL5492052 | 0.79 | CRHR1 (0.50) | CRHR1 | |
| SCHEMBL5497565 | 0.78 | CRHR1 (0.38) | CRHR1SCN9APHGDHCYP1A2CYP2C19 | |
| SCHEMBL5495331 | 0.78 | CRHR1 (0.50) | CRHR1 | |
| SCHEMBL5496957 | 0.78 | CRHR1 (0.43) | CRHR1SCN9APHGDHCYP1A2CYP2C19 | |
| SCHEMBL6746234 | 0.77 | CRHR1 (0.57) | CRHR1PHGDHCYP1A2CYP2C19 | |
| SCHEMBL5497563 | 0.76 | CRHR1 (0.46) | CRHR1CYP2C19 | |
| SCHEMBL5497559 | 0.75 | CRHR1 (0.40) | CRHR1SCN9APHGDHCYP1A2CYP2C19 | |
| SCHEMBL5489958 | 0.73 | CRHR1 (0.55) | CRHR1PHGDH | |
| SCHEMBL5489901 | 0.73 | CRHR1 (0.41) | CRHR1SCN9APHGDHCYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7279474-B2 | Substituted pyrrolo[2,3-d]pyrimidines as antagonists of the corticotropin releasing factor (CRF) | GLAXO GROUP LIMITED (GB) | 2007-10-09 | — | — | US | disclosed |