Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.58 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.54 |
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.53 |
| ▸ | MET | P08581 | 3/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.51 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.49 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5498248 | 1.00 | HRH3 (0.58) | HRH3NR4A2SPHK2METALK | |
| SCHEMBL3274718 | 0.96 | HRH3 (0.62) | HRH3NR4A2SPHK2METMAOB | |
| SCHEMBL3274721 | 0.96 | HRH3 (0.62) | HRH3NR4A2SPHK2METMAOB | |
| Trifluoroacetic Acid SCHEMBL3275405 | 0.90 | MET (0.55) | HRH3NR4A2SPHK2METALK | |
| Trifluoroacetic Acid SCHEMBL3275401 | 0.90 | MET (0.55) | HRH3NR4A2SPHK2METALK | |
| Trifluoroacetic Acid SCHEMBL3275015 | 0.90 | SPHK2 (0.53) | HRH3SPHK2METALKMAOB | |
| Trifluoroacetic Acid SCHEMBL3275018 | 0.90 | SPHK2 (0.53) | HRH3SPHK2METALKMAOB | |
| Trifluoroacetic Acid SCHEMBL5506854 | 0.89 | HRH3 (0.57) | HRH3SPHK2METALKSPHK1 | |
| Trifluoroacetic Acid SCHEMBL3275399 | 0.89 | HRH3 (0.57) | HRH3SPHK2METALKSPHK1 | |
| Trifluoroacetic Acid SCHEMBL12095860 | 0.89 | HRH3 (0.56) | HRH3SPHK2METALKSPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756051-A1 | HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-02-28 | — | — | EP | claimed |
| WO-2005121080-A1 | HISTAMINE H3 RECEPTOR AGENTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-22 | — | — | WO | claimed |
| EP-1756051-B1 | Histamine H3 receptor agents, preparation and therapeutic uses | LILLY CO ELI (US) | 2012-09-12 | — | — | EP | disclosed |