Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.70 |
| ▸ | EGFR | P00533 | 10/20 | 0.68 |
| ▸ | KDR | P35968 | 10/20 | 0.68 |
| ▸ | RET | P07949 | 4/20 | 0.68 |
| ▸ | KIF5B | P33176 | 1/20 | 0.68 |
| ▸ | SRC | P12931 | 6/20 | 0.64 |
| ▸ | AURKA | O14965 | 3/20 | 0.64 |
| ▸ | LCK | P06239 | 2/20 | 0.64 |
| ▸ | MET | P08581 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | LTK | P29376 | 2/20 | 0.64 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.64 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.64 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | FYN | P06241 | 1/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.64 |
| ▸ | TTK | P33981 | 1/20 | 0.64 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5496174 | 0.92 | EGFR (0.69) | BRAFEGFRKDRRETKIF5B | |
| SCHEMBL4421074 | 0.88 | KDR (0.57) | BRAFEGFRKDRRETKIF5B | |
| SCHEMBL12694370 | 0.84 | EGFR (0.85) | BRAFEGFRKDRRETSRC | |
| SCHEMBL5500589 | 0.83 | AURKA (0.54) | BRAFEGFRKDRRETKIF5B | |
| SCHEMBL4687801 | 0.83 | RET (0.66) | EGFRKDRRETKIF5BSRC | |
| SCHEMBL5496725 | 0.83 | KDR (0.62) | BRAFEGFRKDRRETKIF5B | |
| SCHEMBL5500057 | 0.83 | EGFR (0.71) | BRAFEGFRKDRRETKIF5B | |
| SCHEMBL12694406 | 0.82 | BRAF (1.00) | BRAFEGFRKDRRETSRC | |
| SCHEMBL27817044 | 0.82 | AURKA (0.83) | BRAFEGFRKDRRETKIF5B | |
| SCHEMBL4689817 | 0.81 | SRC (0.64) | BRAFEGFRKDRRETKIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218353-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2007-10-17 | — | — | EP | claimed |
| US-6806274-B1 | IMMUNOREGULATION OR IMMUNOSUPPRESSIVE AGENTS; TYROSINE KINASE INHIBITORS; PREVENTING ORGAN TRANSPLANT REJECTION; AUTOIMMUNE CONDITIONS; REDUCED SIDE EFFECTS | ASTRAZENECA UK LIMITED (GB) | 2004-10-19 | — | — | US | claimed |
| EP-1218353-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA UK LTD (GB) | 2007-10-17 | — | — | EP | disclosed |
| US-6806274-B1 | IMMUNOREGULATION OR IMMUNOSUPPRESSIVE AGENTS; TYROSINE KINASE INHIBITORS; PREVENTING ORGAN TRANSPLANT REJECTION; AUTOIMMUNE CONDITIONS; REDUCED SIDE EFFECTS | ASTRAZENECA UK LIMITED (GB) | 2004-10-19 | — | — | US | disclosed |
| EP-1218353-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca UK Limited (GB) | 2002-07-03 | — | — | EP | disclosed |
| WO-2002002534-A1 | QUINAZOLINES WITH THERAPEUTIC USE | ASTRAZENECA AB (SE) | 2002-01-10 | — | — | WO | disclosed |
| WO-2001004102-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 2001-01-18 | — | — | WO | disclosed |