Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 13/20 | 0.51 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4523462 | 0.92 | PTPN1 (0.51) | PTPN1DHFRTRPV1 | |
| SCHEMBL4524961 | 0.92 | PTPN1 (0.52) | PTPN1DHFRNLRP3TRPV1 | |
| SCHEMBL4524484 | 0.91 | PTPN1 (0.52) | PTPN1DHFRTRPV1 | |
| Trifluoroacetic Acid SCHEMBL4534719 | 0.86 | PTPN1 (0.47) | PTPN1DHFRTRPV1 | |
| SCHEMBL4527944 | 0.85 | PTPN1 (0.57) | PTPN1DHFRNLRP3TRPV1 | |
| SCHEMBL4520756 | 0.84 | PTPN1 (0.47) | PTPN1DHFRTRPV1 | |
| SCHEMBL5528686 | 0.83 | PTPN1 (0.47) | PTPN1DHFRTRPV1 | |
| SCHEMBL4384323 | 0.82 | PTPN1 (0.76) | PTPN1 | |
| SCHEMBL4523940 | 0.81 | PTPN1 (0.64) | PTPN1NLRP3 | |
| SCHEMBL4531449 | 0.80 | PTPN1 (0.53) | PTPN1NLRP3TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812409-A1 | AMINOQUINAZOLINES COMPOUNDS | F. Hoffmann-Roche AG (CH) | 2007-08-01 | — | — | EP | claimed |
| WO-2006050843-A1 | AMINOQUINAZOLINES COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-05-18 | — | — | WO | claimed |