Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 10/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.36 |
| ▸ | CYBB | P04839 | 1/20 | 0.35 |
| ▸ | NCF1 | P14598 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4524484 | 0.91 | PTPN1 (0.52) | PTPN1TRPV1DHFRAR | |
| SCHEMBL4529999 | 0.88 | PIK3CA (0.37) | PTPN1CYBBNCF1PIK3CADHFR | |
| SCHEMBL5498432 | 0.83 | PTPN1 (0.51) | PTPN1TRPV1DHFR | |
| SCHEMBL4523462 | 0.83 | PTPN1 (0.51) | PTPN1TRPV1DHFR | |
| SCHEMBL4524961 | 0.81 | PTPN1 (0.52) | PTPN1TRPV1DHFR | |
| SCHEMBL4523940 | 0.77 | PTPN1 (0.64) | PTPN1 | |
| SCHEMBL4527944 | 0.77 | PTPN1 (0.57) | PTPN1TRPV1DHFR | |
| SCHEMBL4528751 | 0.76 | DHFR (0.39) | PTPN1PIK3CADHFR | |
| SCHEMBL4520756 | 0.76 | PTPN1 (0.47) | PTPN1TRPV1DHFR | |
| Trifluoroacetic Acid SCHEMBL4534719 | 0.76 | PTPN1 (0.47) | PTPN1TRPV1DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812409-A1 | AMINOQUINAZOLINES COMPOUNDS | F. Hoffmann-Roche AG (CH) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006050843-A1 | AMINOQUINAZOLINES COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-05-18 | — | — | WO | disclosed |