SCHEMBL5498501

SCHEMBL5498501

CC(C=O)Cc1ccc(C(=O)O)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 2/20 0.56
TSHR P16473 2/20 0.56
ALDH1A1 P00352 4/20 0.52
ANPEP P15144 1/20 0.50
ENPEP Q07075 1/20 0.50
ACACB O00763 1/20 0.48
FOLH1 Q04609 4/20 0.45
KMT2A Q03164 3/20 0.44
ADRB1 P08588 1/20 0.44
ADRB3 P13945 1/20 0.44
RXRA P19793 1/20 0.44
RXRB P28702 1/20 0.44
KDM4E B2RXH2 1/20 0.43
MEN1 O00255 1/20 0.43
USP2 O75604 1/20 0.43
POLB P06746 1/20 0.43
GAA P10253 1/20 0.43
MAPT P10636 1/20 0.43
THRB P10828 1/20 0.43
NR4A1 P22736 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11663636 0.85 TSHR (0.56) TP53TSHRALDH1A1ACACBKMT2A
SCHEMBL452233 0.80 PTGS1 (0.60) TP53TSHRALDH1A1ANPEPENPEP
SCHEMBL27959311 0.80 PTGS1 (0.60) TP53TSHRALDH1A1ANPEPENPEP
SCHEMBL7526053 0.80 TSHR (0.54) TP53TSHRALDH1A1ACACBKMT2A
SCHEMBL21613912 0.80 TSHR (0.50) TP53TSHRALDH1A1ACACBKMT2A
SCHEMBL28533988 0.80 TSHR (0.50) TP53TSHRALDH1A1KMT2AADRB3
SCHEMBL5501294 0.79 ALDH1A1 (0.48) TP53TSHRALDH1A1ANPEPENPEP
SCHEMBL13889195 0.79 TP53 (0.61) TP53TSHRFOLH1GAAMAPT
SCHEMBL14473200 0.79 TP53 (0.61) TP53TSHRFOLH1GAAMAPT
SCHEMBL13743729 0.79 TP53 (0.61) TP53TSHRFOLH1GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1625123-A4 3-(2-AMINO-1-AZACYCLYL)-5-ARYL-1,2,4-OXADIAZOLES AS S1P RECEPTOR AGONISTS MERCK & CO INC (US) 2007-08-29 EP disclosed
EP-1670463-A2 3,5-ARYL, HETEROARYL OR CYCLOALKYL SUBSTITUTED-1,2,4-OXADIAZOLES AS S1P RECEPTOR AGONISTS Merck & Co., Inc. (US) 2006-06-21 EP disclosed
EP-1625123-A2 3-(2-AMINO-1-AZACYCLYL)-5-ARYL-1,2,4-OXADIAZOLES AS S1P RECEPTOR AGONISTS Merck & Co., Inc. (US) 2006-02-15 EP disclosed
WO-2005032465-A2 3,5-ARYL, HETEROARYL OR CYCLOALKYL SUBSTITUTED-1,2,4-OXADIAZOLES AS S1P RECEPTOR AGONISTS MERCK & CO., INC. (US) 2005-04-14 WO disclosed
WO-2004103279-A2 3-(2-AMINO-1-AZACYCLYL)-5-ARYL-1,2,4-OXADIAZOLES AS S1P RECEPTOR AGONISTS MERCK & CO., INC. (US) 2004-12-02 WO disclosed