Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 10/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2697967 | 1.00 | PIK3CA (0.39) | PIK3CAHSD11B1NPY5RCRBNDDB1 | |
| SCHEMBL551083 | 1.00 | PIK3CA (0.39) | PIK3CAHSD11B1NPY5RCRBNDDB1 | |
| SCHEMBL551141 | 0.92 | HSD11B1 (0.42) | PIK3CAHSD11B1NPY5RCRBNDDB1 | |
| SCHEMBL2700785 | 0.92 | HSD11B1 (0.42) | PIK3CAHSD11B1NPY5RCRBNDDB1 | |
| SCHEMBL551140 | 0.92 | HSD11B1 (0.42) | PIK3CAHSD11B1NPY5RCRBNDDB1 | |
| SCHEMBL2700789 | 0.92 | HSD11B1 (0.42) | PIK3CAHSD11B1NPY5RCRBNDDB1 | |
| SCHEMBL550906 | 0.88 | PIK3CA (0.39) | PIK3CAHSD11B1CRBNDDB1HCRTR2 | |
| SCHEMBL551432 | 0.88 | HSD11B1 (0.45) | PIK3CAHSD11B1CRBNDDB1HCRTR2 | |
| SCHEMBL2700334 | 0.88 | PIK3CA (0.39) | PIK3CAHSD11B1CRBNDDB1HCRTR2 | |
| SCHEMBL550971 | 0.88 | PIK3CA (0.39) | PIK3CAHSD11B1CRBNDDB1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |