Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 17/20 | 0.42 |
| ▸ | F2 | P00734 | 10/20 | 0.42 |
| ▸ | PLG | P00747 | 7/20 | 0.42 |
| ▸ | TMPRSS11D | O60235 | 2/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | HPN | P05981 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | F7 | P08709 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6544447 | 0.99 | F10 (0.42) | F10F2PLGTMPRSS11DPRSS1 | |
| SCHEMBL308627 | 0.91 | F2 (0.38) | F10F2PLGTMPRSS11DPRSS1 | |
| SCHEMBL4359370 | 0.91 | F2 (0.38) | F10F2PLGTMPRSS11DPRSS1 | |
| SCHEMBL2167336 | 0.91 | TMPRSS11D (0.51) | F10F2PLGTMPRSS11DPRSS1 | |
| Hydrochloric Acid SCHEMBL308853 | 0.90 | F10 (0.37) | F10F2PLGTMPRSS11DPRSS1 | |
| SCHEMBL5494187 | 0.90 | F7 (0.46) | F10F2PLGTMPRSS11DPRSS1 | |
| Hydrochloric Acid SCHEMBL6853389 | 0.90 | TMPRSS11D (0.50) | F10F2PLGTMPRSS11DPRSS1 | |
| Hydrochloric Acid SCHEMBL307960 | 0.89 | F7 (0.45) | F10F2PLGTMPRSS11DPRSS1 | |
| SCHEMBL5497165 | 0.87 | F10 (0.42) | F10F2PLGTMPRSS11DPRSS1 | |
| SCHEMBL14628420 | 0.87 | F10 (0.49) | F10F2PLGTMPRSS11DPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453852-B1 | SELECTIVE UROKINASE INHIBITORS | WILEX AG (DE) | 2007-01-17 | — | — | EP | disclosed |
| EP-1453852-A2 | SELECTIVE UROKINASE INHIBITORS | Wilex AG (DE) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003053999-A2 | SELECTIVE ARYLGUANIDINE PEPTIDES AS UROKINASE INHIBITORS | WILEX AG (DE) | 2003-07-03 | — | — | WO | disclosed |