Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS11D | O60235 | 11/20 | 0.51 |
| ▸ | F2 | P00734 | 11/20 | 0.51 |
| ▸ | F10 | P00742 | 9/20 | 0.51 |
| ▸ | PLG | P00747 | 8/20 | 0.51 |
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.43 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
| ▸ | PROC | P04070 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6853389 | 0.99 | TMPRSS11D (0.50) | TMPRSS11DF2F10PLGTMPRSS2 | |
| SCHEMBL5499067 | 0.91 | F10 (0.42) | TMPRSS11DF2F10PLGPRSS1 | |
| SCHEMBL3805077 | 0.90 | F10 (0.43) | TMPRSS11DF2F10PLGPRSS1 | |
| Hydrochloric Acid SCHEMBL6544447 | 0.90 | F10 (0.42) | TMPRSS11DF2F10PLGPRSS1 | |
| Hydrochloric Acid SCHEMBL2828492 | 0.89 | F10 (0.42) | TMPRSS11DF2F10PLGPRSS1 | |
| SCHEMBL8346530 | 0.88 | F2 (0.57) | TMPRSS11DF2F10PLGTMPRSS2 | |
| SCHEMBL49083 | 0.87 | TMPRSS11D (0.49) | TMPRSS11DF2F10PLGTMPRSS2 | |
| SCHEMBL635785 | 0.87 | TMPRSS11D (0.53) | TMPRSS11DF2F10PLGTMPRSS2 | |
| SCHEMBL2821370 | 0.83 | F10 (0.38) | TMPRSS11DF2F10PLGPRSS1 | |
| SCHEMBL2167189 | 0.83 | TMPRSS11D (0.50) | TMPRSS11DF2F10PLGTMPRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130224131-A1 | 4-AMIDINO BENZYLAMINES FOR COSMETIC AND/OR DERMATOLOGICAL USE | DSM IP ASSETS B.V. (NL) | 2013-08-29 | — | — | US | claimed |
| US-20110177140-A1 | 4-AMIDINO BENZYLAMINES FOR COSMETIC AND/OR DERMATOLOGICAL USE | DSM IP ASSETS B.V. (NL) | 2011-07-21 | — | — | US | claimed |
| EP-2197409-A1 | 4-AMIDINO BENZYLAMINES FOR COSMETIC AND/OR DERMATOLOGICAL USE | DSM IP Assets B.V. (NL) | 2010-06-23 | — | — | EP | claimed |
| WO-2009026949-A1 | 4-AMIDINO BENZYLAMINES FOR COSMETIC AND/OR DERMATOLOGICAL USE | DSM IP ASSETS B.V. (NL) | 2009-03-05 | — | — | WO | claimed |
| US-20130224131-A1 | 4-AMIDINO BENZYLAMINES FOR COSMETIC AND/OR DERMATOLOGICAL USE | DSM IP ASSETS B.V. (NL) | 2013-08-29 | — | — | US | disclosed |
| US-8476306-B2 | Urokinase inhibitors, production and use thereof | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2013-07-02 | — | — | US | disclosed |
| US-20110177140-A1 | 4-AMIDINO BENZYLAMINES FOR COSMETIC AND/OR DERMATOLOGICAL USE | DSM IP ASSETS B.V. (NL) | 2011-07-21 | — | — | US | disclosed |
| US-20110065799-A1 | UROKINASE INHIBITORS, PRODUCTION AND USE THEREOF | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2011-03-17 | — | — | US | disclosed |
| US-7838560-B2 | for the therapy, prophylaxis and diagnosis of a tumor; benzylsulfonyl-D-Ser-Glu-4-amidinobenzylamidexTFA | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2010-11-23 | — | — | US | disclosed |
| EP-2197409-A1 | 4-AMIDINO BENZYLAMINES FOR COSMETIC AND/OR DERMATOLOGICAL USE | DSM IP Assets B.V. (NL) | 2010-06-23 | — | — | EP | disclosed |
| WO-2009026949-A1 | 4-AMIDINO BENZYLAMINES FOR COSMETIC AND/OR DERMATOLOGICAL USE | DSM IP ASSETS B.V. (NL) | 2009-03-05 | — | — | WO | disclosed |
| EP-1485345-B1 | UROKINASE INHIBITORS, PRODUCTION AND USE THEREOF | CURACYTE AG (DE) | 2008-06-25 | — | — | EP | disclosed |
| US-20050176993-A1 | Urokinase inhibitors, production and use thereof | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2005-08-11 | — | — | US | disclosed |
| EP-1294742-B1 | UROKINASE INHIBITORS | CURACYTE AG (DE) | 2004-03-31 | — | — | EP | disclosed |
| EP-1294742-A2 | UROKINASE INHIBITORS | Curacyte AG (DE) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001096286-A2 | UROKINASE INHIBITORS | CURACYTE AG (DE) | 2001-12-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110177140-A1 | 4-AMIDINO BENZYLAMINES FOR COSMETIC AND/OR DERMATOLOGICAL USE | CUTA, PADI4, HNMT | TMPRSS11D 1344/4885F2 473/4885F10 838/4885 |
| US-20130224131-A1 | 4-AMIDINO BENZYLAMINES FOR COSMETIC AND/OR DERMATOLOGICAL USE | CUTA, PADI4, HNMT | TMPRSS11D 1344/4885F2 473/4885F10 838/4885 |
| US-20050176993-A1 | Urokinase inhibitors, production and use thereof | PLAU, PLAUR, SERPINE1 | TMPRSS11D 163/4885F2 61/4885F10 94/4885 |
| US-20110065799-A1 | UROKINASE INHIBITORS, PRODUCTION AND USE THEREOF | PLAU, PLAUR, SERPINE1 | TMPRSS11D 163/4885F2 61/4885F10 94/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.