Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | GPR17 | Q13304 | 5/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.38 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5498679 | 0.86 | TBXAS1 (0.47) | TBXAS1FFAR1APEX1GPR17FFAR4 | |
| SCHEMBL7699710 | 0.74 | AKR1C2 (0.46) | TBXAS1PTPN5PDE3BPDE3ACYP1A2 | |
| SCHEMBL18509470 | 0.73 | APEX1 (0.59) | TBXAS1FFAR1APEX1GPR17PDGFRB | |
| SCHEMBL21392019 | 0.72 | GPR17 (0.51) | FFAR1APEX1GPR17EGFRCYP1A2 | |
| SCHEMBL18509467 | 0.70 | APEX1 (0.44) | TBXAS1APEX1GPR17EGFR | |
| SCHEMBL5503081 | 0.69 | PTPN5 (0.41) | TBXAS1PTPN5PDE3BPDE3A | |
| SCHEMBL5500896 | 0.69 | PTPN5 (0.41) | TBXAS1PTPN5PDE3BPDE3A | |
| SCHEMBL18509955 | 0.69 | HTR2A (0.63) | TBXAS1APEX1GPR17EGFR | |
| SCHEMBL7931226 | 0.69 | MME (0.40) | PTPN5CYP1A2 | |
| SCHEMBL5500665 | 0.68 | PTPN5 (0.41) | TBXAS1PTPN5PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1039914-A4 | CYCLOOXYGENASE-2 INHIBITION | CORNELL RES FOUNDATION INC (US) | 2007-06-27 | — | — | EP | disclosed |
| EP-1146789-A4 | TREATING CANCERS ASSOCIATED WITH OVEREXPRESSION OF HER-2/NEU | CORNELL RES FOUNDATION INC (US) | 2007-02-14 | — | — | EP | disclosed |
| EP-1146789-A1 | TREATING CANCERS ASSOCIATED WITH OVEREXPRESSION OF HER-2/NEU | CORNELL RESEARCH FOUNDATION, INC. (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1039914-A1 | CYCLOOXYGENASE-2 INHIBITION | CORNELL RESEARCH FOUNDATION, INC. (US) | 2000-10-04 | — | — | EP | disclosed |
| WO-2000044225-A1 | TREATING CANCERS ASSOCIATED WITH OVEREXPRESSION OF HER-2/neu | CORNELL RESEARCH FOUNDATION, INC. (US) | 2000-08-03 | — | — | WO | disclosed |
| WO-1999030721-A1 | CYCLOOXYGENASE-2 INHIBITION | CORNELL RESEARCH FOUNDATION, INC. (US) | 1999-06-24 | — | — | WO | disclosed |