Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2B | Q14289 | 18/20 | 0.58 |
| ▸ | PTK2 | Q05397 | 18/20 | 0.58 |
| ▸ | AURKA | O14965 | 2/20 | 0.56 |
| ▸ | CDK1 | P06493 | 2/20 | 0.56 |
| ▸ | CDK7 | P50613 | 2/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.56 |
| ▸ | STK16 | O75716 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | PAK4 | O96013 | 1/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.56 |
| ▸ | PRKCG | P05129 | 1/20 | 0.56 |
| ▸ | INSR | P06213 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5499554 | 0.91 | PTK2B (0.52) | PTK2BPTK2AURKACDK1CDK7 | |
| SCHEMBL3154674 | 0.90 | PTK2B (0.70) | PTK2BPTK2AURKACDK1CDK7 | |
| SCHEMBL3155042 | 0.86 | PTK2B (0.67) | PTK2BPTK2AURKACDK1CDK7 | |
| SCHEMBL5185860 | 0.85 | PTK2 (0.62) | PTK2BPTK2AURKACDK1CDK7 | |
| SCHEMBL3160254 | 0.83 | PTK2B (0.73) | PTK2BPTK2AURKACDK1CDK7 | |
| SCHEMBL3151722 | 0.81 | PTK2B (0.73) | PTK2BPTK2AURKACDK1CDK7 | |
| SCHEMBL3146640 | 0.80 | PTK2 (0.76) | PTK2BPTK2AURKACDK1CDK7 | |
| SCHEMBL5185869 | 0.78 | PTK2 (0.65) | PTK2BPTK2AURKACDK1CDK7 | |
| SCHEMBL5186497 | 0.78 | PTK2 (0.54) | PTK2BPTK2AURKACDK1CDK7 | |
| SCHEMBL3160493 | 0.78 | PTK2B (0.75) | PTK2BPTK2AURKACDK1CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751143-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | Pfizer Products Incorporated (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005111023-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PRODUCTS INC. (US) | 2005-11-24 | — | — | WO | disclosed |