Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.51 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 6/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5503332 | 0.81 | AR (0.63) | ARALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL5114895 | 0.73 | PTGDR2 (0.61) | — | |
| SCHEMBL5503450 | 0.73 | AR (0.63) | ARALDH1A1GRIN2AGRIN2BGRIN2C | |
| SCHEMBL14304932 | 0.71 | BCHE (0.86) | ARALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL9514166 | 0.71 | ALDH1A1 (1.00) | ARALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL14303261 | 0.70 | BCHE (0.83) | ARALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL14304381 | 0.70 | BCHE (0.83) | ARALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL6141660 | 0.70 | BCHE (0.83) | ARALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL14303260 | 0.70 | BCHE (0.83) | ARALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL14304387 | 0.70 | BCHE (0.83) | ARALDH1A1MAPTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784182-A1 | 2-SULFANYL-BENZIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2007-05-16 | — | — | EP | claimed |
| WO-2006021418-A1 | 2-SULFANYL-BENZOIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-02 | — | — | WO | claimed |