Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mibefradil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H known ✓ | O95180 | 10/20 | 0.99 |
| ▸ | CACNA1G known ✓ | O43497 | 1/20 | 0.99 |
| ▸ | CACNA1I known ✓ | Q9P0X4 | 1/20 | 0.99 |
| ▸ | MAPT | P10636 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 1.00 |
| ▸ | CACNA1C | Q13936 | 8/20 | 0.99 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.99 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.99 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.99 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.99 |
| ▸ | NPC1 | O15118 | 1/20 | 0.99 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.99 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mibefradil SCHEMBL29412446 | 1.00 | MAPT (1.00) | MAPTMEN1KMT2ANPSR1ABCB11 | |
| Mibefradil SCHEMBL7400127 | 1.00 | MAPT (1.00) | MAPTMEN1KMT2ANPSR1ABCB11 | |
| Mibefradil SCHEMBL120810 | 1.00 | MAPT (1.00) | MAPTMEN1KMT2ANPSR1ABCB11 | |
| Mibefradil SCHEMBL908985 | 1.00 | MAPT (1.00) | MAPTMEN1KMT2ANPSR1ABCB11 | |
| Mibefradil SCHEMBL18210637 | 0.99 | NPSR1 (1.00) | MAPTMEN1KMT2ANPSR1ABCB11 | |
| Mibefradil SCHEMBL2230258 | 0.99 | CACNA1H (1.00) | MAPTMEN1KMT2ANPSR1ABCB11 | |
| Mibefradil SCHEMBL7708100 | 0.99 | CACNA1H (1.00) | MAPTMEN1KMT2ANPSR1ABCB11 | |
| Mibefradil SCHEMBL29359482 | 0.99 | CACNA1H (1.00) | MAPTMEN1KMT2ANPSR1ABCB11 | |
| Mibefradil SCHEMBL22968530 | 0.99 | CACNA1H (1.00) | MAPTMEN1KMT2ANPSR1ABCB11 | |
| Mibefradil SCHEMBL7265837 | 0.99 | CACNA1H (1.00) | MAPTMEN1KMT2ANPSR1ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737539-A1 | THERAPEUTIC COMBINATION FOR TREATMENT OF ALZHEIMERS DISEASE | Warner-Lambert Company LLC (US) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005099823-A1 | THERAPEUTIC COMBINATION FOR TREATMENT OF ALZHEIMERS DISEASE | WARNER-LAMBERT COMPANY LLC (US) | 2005-10-27 | — | — | WO | disclosed |