Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mibefradil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H known ✓ | O95180 | 10/20 | 1.00 |
| ▸ | CACNA1G known ✓ | O43497 | 1/20 | 1.00 |
| ▸ | CACNA1I known ✓ | Q9P0X4 | 1/20 | 1.00 |
| ▸ | CACNA1C | Q13936 | 8/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 7/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 1.00 |
| ▸ | CACNA1B | Q00975 | 3/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 2/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | NPC1 | O15118 | 1/20 | 1.00 |
| ▸ | CACNA1F | O60840 | 1/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mibefradil SCHEMBL22968530 | 1.00 | CACNA1H (1.00) | CACNA1HCACNA1CCYP3A4CYP2D6MAPT | |
| Mibefradil SCHEMBL6789173 | 1.00 | CACNA1H (1.00) | CACNA1HCACNA1CCYP3A4CYP2D6MAPT | |
| Mibefradil SCHEMBL39551 | 1.00 | CACNA1H (1.00) | CACNA1HCACNA1CCYP3A4CYP2D6MAPT | |
| Mibefradil SCHEMBL7265837 | 1.00 | CACNA1H (1.00) | CACNA1HCACNA1CCYP3A4CYP2D6MAPT | |
| Mibefradil SCHEMBL30170543 | 1.00 | CACNA1H (1.00) | CACNA1HCACNA1CCYP3A4CYP2D6MAPT | |
| Mibefradil SCHEMBL29364574 | 1.00 | CACNA1H (1.00) | CACNA1HCACNA1CCYP3A4CYP2D6MAPT | |
| Mibefradil SCHEMBL29359482 | 1.00 | CACNA1H (1.00) | CACNA1HCACNA1CCYP3A4CYP2D6MAPT | |
| Mibefradil SCHEMBL2230258 | 1.00 | CACNA1H (1.00) | CACNA1HCACNA1CCYP3A4CYP2D6MAPT | |
| Mibefradil SCHEMBL908985 | 0.99 | MAPT (1.00) | CACNA1HCACNA1CCYP3A4CYP2D6MAPT | |
| Mibefradil SCHEMBL120810 | 0.99 | MAPT (1.00) | CACNA1HCACNA1CCYP3A4CYP2D6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998049147-A1 | PREPARATION OF MIBEFRADIL III | F. HOFFMANN-LA ROCHE AG (CH) | 1998-11-05 | — | — | WO | claimed |
| JP-11035483-A | — | — | None | — | — | JP | disclosed |
| EP-2414543-B1 | GENETIC MARKERS FOR RISK MANAGEMENT OF ATRIAL FIBRILLATION AND STROKE | DECODE GENETICS EHF (IS) | 2016-10-12 | — | — | EP | disclosed |
| US-8795963-B2 | Genetic markers for risk management of atrial fibrillation and stroke | DECODE GENETICS EHF. (IS) | 2014-08-05 | — | — | US | disclosed |
| US-6358706-B1 | NUCLEOTIDE SEQUENCES CODING MEMBRANE PROTEIN; FOR USE IN TREATMENT OF EPILEPSY, SCHIZOPHRENIA, DEPRESSION, SLEEP, STRESS, MUSCLE, ENDOCRINE, RESPIRATORY, FERTILITY, CONTRACEPTIVE, CARDIOVASCULAR DISORDERS AND ATHEROSCLEROSIS | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-03-19 | — | — | US | disclosed |
| JP-H1135483-A | THERAPEUTIC AGENT OR PREVENTING AGENT FOR POLLAKIURIA OR INCONTINENCE OF URINE | NIPPON KAYAKU CO LTD | 1999-02-09 | — | — | JP | disclosed |