Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.54 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GLS | O94925 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15155439 | 0.91 | CYP19A1 (0.53) | CYP19A1TBXAS1MAPTKDM4ELMNA | |
| SCHEMBL828039 | 0.89 | CYP19A1 (0.51) | CYP19A1TBXAS1MAPTKDM4ELMNA | |
| SCHEMBL7747842 | 0.86 | LOXL2 (0.60) | CYP19A1TBXAS1MAPTKDM4ELMNA | |
| SCHEMBL6629717 | 0.84 | MAPT (0.54) | CYP19A1TBXAS1MAPTKDM4ELMNA | |
| Hydrochloric Acid SCHEMBL11972049 | 0.82 | MAPT (0.52) | CYP19A1TBXAS1MAPTKDM4ELMNA | |
| SCHEMBL6970292 | 0.81 | CYP19A1 (0.54) | CYP19A1TBXAS1MAPTKDM4ELMNA | |
| SCHEMBL22497966 | 0.81 | CYP19A1 (0.54) | CYP19A1TBXAS1MAPTKDM4ELMNA | |
| SCHEMBL5537149 | 0.81 | CYP19A1 (0.54) | CYP19A1TBXAS1MAPTKDM4ELMNA | |
| SCHEMBL6114797 | 0.81 | CYP19A1 (0.54) | CYP19A1TBXAS1MAPTKDM4ELMNA | |
| SCHEMBL4394904 | 0.81 | CYP19A1 (0.54) | CYP19A1TBXAS1MAPTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1791833-A2 | 4-(CONDENSED CYCLICMETHYL)-IMIDAZOLE-2-THIONES ACTING AS ALPHA2 ADRENERGIC AGONISTS | Allergan, Inc. (US) | 2007-06-06 | — | — | EP | disclosed |
| WO-2006036497-A2 | 4-(CONDENSED CYCLICMETHYL)-IMIDAZOLE-2-THIONES ACTING AS ALPHA2 ADRENERGIC AGONISTS | ALLERGAN, INC. (US) | 2006-04-06 | — | — | WO | disclosed |