Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.54 |
| ▸ | BACE1 | P56817 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | ESR1 | P03372 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.45 |
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3968836 | 0.87 | NPSR1 (0.58) | MEN1KMT2AKDM4EALDH1A1NPSR1 | |
| SCHEMBL3482970 | 0.83 | MEN1 (0.61) | MEN1KMT2AKDM4EALDH1A1NPSR1 | |
| SCHEMBL28161374 | 0.83 | ALDH1A1 (0.54) | MEN1KMT2AKDM4EALDH1A1NPSR1 | |
| SCHEMBL3483273 | 0.82 | MEN1 (0.64) | MEN1KMT2AKDM4EALDH1A1NPSR1 | |
| SCHEMBL14628370 | 0.82 | NPSR1 (0.72) | MEN1KMT2AKDM4EALDH1A1NPSR1 | |
| SCHEMBL13911245 | 0.80 | ALDH1A1 (0.60) | MEN1KMT2AKDM4EALDH1A1NPSR1 | |
| SCHEMBL5566938 | 0.79 | GAA (0.47) | KMT2AALDH1A1NPSR1BACE1TSHR | |
| SCHEMBL13911249 | 0.79 | KDM4E (0.55) | MEN1KMT2AKDM4EALDH1A1NPSR1 | |
| SCHEMBL13900676 | 0.78 | KDM4E (0.59) | MEN1KMT2AKDM4EALDH1A1NPSR1 | |
| SCHEMBL13900692 | 0.78 | ESR2 (0.56) | MEN1KMT2AKDM4EALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549306-A4 | SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH CORP (US) | 2007-06-06 | — | — | EP | claimed |
| EP-1549306-A1 | SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | Wyeth (US) | 2005-07-06 | — | — | EP | claimed |
| WO-2003103660-A1 | SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH (US) | 2003-12-18 | — | — | WO | claimed |