Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | OTUD7B | Q6GQQ9 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2699786 | 1.00 | CRBN (0.51) | CRBNPIK3CAHSD11B1MEN1ALDH1A1 | |
| SCHEMBL549541 | 1.00 | CRBN (0.51) | CRBNPIK3CAHSD11B1MEN1ALDH1A1 | |
| SCHEMBL550100 | 1.00 | CRBN (0.51) | CRBNPIK3CAHSD11B1MEN1ALDH1A1 | |
| SCHEMBL2699780 | 1.00 | CRBN (0.51) | CRBNPIK3CAHSD11B1MEN1ALDH1A1 | |
| SCHEMBL549540 | 1.00 | CRBN (0.51) | CRBNPIK3CAHSD11B1MEN1ALDH1A1 | |
| SCHEMBL2699725 | 0.93 | CRBN (0.59) | CRBNPIK3CAMEN1ALDH1A1KMT2A | |
| SCHEMBL550039 | 0.93 | CRBN (0.59) | CRBNPIK3CAMEN1ALDH1A1KMT2A | |
| SCHEMBL551023 | 0.93 | CRBN (0.59) | CRBNPIK3CAMEN1ALDH1A1KMT2A | |
| SCHEMBL2699729 | 0.93 | CRBN (0.59) | CRBNPIK3CAMEN1ALDH1A1KMT2A | |
| SCHEMBL551024 | 0.93 | CRBN (0.59) | CRBNPIK3CAMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |