Sugi Predict

Sugi Predict / Compounds / SCHEMBL549541

SCHEMBL549541

SCHEMBL549541

CC(=O)Nc1ccc(-c2ccc(N3CCC[C@]4(CCN(C5CCC(O)CC5)C4=O)C3)nc2)cc1

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 2/20 0.51
▸ PIK3CA P42336 1/20 0.40
▸ HSD11B1 P28845 6/20 0.39
▸ MEN1 O00255 2/20 0.39
▸ ALDH1A1 P00352 2/20 0.39
▸ KMT2A Q03164 2/20 0.39
▸ HRH3 Q9Y5N1 1/20 0.38
▸ DDB1 Q16531 1/20 0.37
▸ KDM4E B2RXH2 2/20 0.37
▸ MAPT P10636 2/20 0.37
▸ RXFP1 Q9HBX9 1/20 0.36
▸ GAA P10253 1/20 0.35
▸ OTUD7B Q6GQQ9 2/20 0.35
▸ CYP1A2 P05177 1/20 0.35
▸ CYP3A4 P08684 1/20 0.35
▸ CYP2C19 P33261 1/20 0.35
▸ GFER P55789 1/20 0.35
▸ PDE7A Q13946 1/20 0.35
▸ SCD O00767 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2699786 1.00 CRBN (0.51) CRBNPIK3CAHSD11B1MEN1ALDH1A1
SCHEMBL550100 1.00 CRBN (0.51) CRBNPIK3CAHSD11B1MEN1ALDH1A1
SCHEMBL2699780 1.00 CRBN (0.51) CRBNPIK3CAHSD11B1MEN1ALDH1A1
SCHEMBL550099 1.00 CRBN (0.51) CRBNPIK3CAHSD11B1MEN1ALDH1A1
SCHEMBL549540 1.00 CRBN (0.51) CRBNPIK3CAHSD11B1MEN1ALDH1A1
SCHEMBL2699725 0.93 CRBN (0.59) CRBNPIK3CAMEN1ALDH1A1KMT2A
SCHEMBL550039 0.93 CRBN (0.59) CRBNPIK3CAMEN1ALDH1A1KMT2A
SCHEMBL551023 0.93 CRBN (0.59) CRBNPIK3CAMEN1ALDH1A1KMT2A
SCHEMBL2699729 0.93 CRBN (0.59) CRBNPIK3CAMEN1ALDH1A1KMT2A
SCHEMBL551024 0.93 CRBN (0.59) CRBNPIK3CAMEN1ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8563570-B2 Lactam compounds and their use as pharmaceuticals INCYTE CORPORATION (US) 2013-10-22 — — US claimed
US-20120122858-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS INCYTE CORPORATION (US) 2012-05-17 — — US claimed
US-20090291946-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS INCYTE CORPORATION (US) 2009-11-26 — — US claimed
US-8563570-B2 Lactam compounds and their use as pharmaceuticals INCYTE CORPORATION (US) 2013-10-22 — — US disclosed
US-20120122858-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS INCYTE CORPORATION (US) 2012-05-17 — — US disclosed
US-8110581-B2 Lactam compounds and their use as pharmaceuticals INCYTE CORPORATION (US) 2012-02-07 — — US disclosed
US-20090291946-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS INCYTE CORPORATION (US) 2009-11-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090291946-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS HSD11B1, HSD11B2, HSD17B1 CRBN 2898/4885PIK3CA 599/4885HSD11B1 1/4885
US-20120122858-A1 LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS HSD11B1, HSD11B2, HSD17B1 CRBN 2898/4885PIK3CA 599/4885HSD11B1 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.