Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 6/20 | 0.74 |
| ▸ | PLA2G5 | P39877 | 3/20 | 0.74 |
| ▸ | NOD1 | Q9Y239 | 3/20 | 0.51 |
| ▸ | CES2 | O00748 | 4/20 | 0.50 |
| ▸ | CES1 | P23141 | 4/20 | 0.50 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | PPARD | Q03181 | 2/20 | 0.44 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.44 |
| ▸ | TLR2 | O60603 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5501051 | 1.00 | PLA2G2A (0.74) | PLA2G2APLA2G5NOD1CES2CES1 | |
| SCHEMBL2769449 | 0.88 | PLA2G2A (0.72) | PLA2G2APLA2G5NOD1CES2CES1 | |
| SCHEMBL2770510 | 0.88 | PLA2G2A (0.72) | PLA2G2APLA2G5NOD1CES2CES1 | |
| SCHEMBL1893081 | 0.85 | PLA2G2A (0.68) | PLA2G2APLA2G5NOD1CES2CES1 | |
| SCHEMBL2770844 | 0.85 | PLA2G2A (0.68) | PLA2G2APLA2G5NOD1PLA2G4AMEN1 | |
| SCHEMBL5162305 | 0.85 | PLA2G2A (0.68) | PLA2G2APLA2G5NOD1CES2CES1 | |
| SCHEMBL27081338 | 0.85 | PLA2G2A (1.00) | PLA2G2APLA2G5NOD1CES2CES1 | |
| SCHEMBL2770848 | 0.85 | PLA2G2A (0.68) | PLA2G2APLA2G5NOD1PLA2G4AMEN1 | |
| SCHEMBL5162407 | 0.85 | PLA2G2A (0.68) | PLA2G2APLA2G5NOD1CES2CES1 | |
| SCHEMBL27081336 | 0.85 | PLA2G2A (1.00) | PLA2G2APLA2G5NOD1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490328-A4 | COMPOSITIONS AND METHODS FOR INHIBITION OF PHOSPHOLIPASE A2 MEDIATED INFLAMMATION | UNIV CALIFORNIA (US) | 2007-08-15 | — | — | EP | disclosed |
| EP-1490328-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF PHOSPHOLIPASE A2 MEDIATED INFLAMMATION | The Regents of The University of California (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003076389-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF PHOSPHOLIPASE A2 MEDIATED INFLAMMATION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2003-09-18 | — | — | WO | disclosed |