Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2699529 | 1.00 | SCN9A (0.43) | SCN9AHSD11B1NOTUMLMNASMN1; SMN2 | |
| SCHEMBL2699011 | 1.00 | SCN9A (0.43) | SCN9AHSD11B1NOTUMLMNASMN1; SMN2 | |
| SCHEMBL550118 | 1.00 | SCN9A (0.43) | SCN9AHSD11B1NOTUMLMNASMN1; SMN2 | |
| SCHEMBL17082160 | 1.00 | SCN9A (0.43) | SCN9AHSD11B1NOTUMLMNASMN1; SMN2 | |
| SCHEMBL549672 | 1.00 | SCN9A (0.43) | SCN9AHSD11B1NOTUMLMNASMN1; SMN2 | |
| SCHEMBL4570199 | 1.00 | SCN9A (0.43) | SCN9AHSD11B1NOTUMLMNASMN1; SMN2 | |
| SCHEMBL549671 | 1.00 | SCN9A (0.43) | SCN9AHSD11B1NOTUMLMNASMN1; SMN2 | |
| SCHEMBL550605 | 0.91 | SCN9A (0.40) | SCN9AHSD11B1NOTUMDRD2 | |
| SCHEMBL17082152 | 0.91 | SCN9A (0.40) | SCN9AHSD11B1NOTUMDRD2 | |
| SCHEMBL2697981 | 0.91 | SCN9A (0.40) | SCN9AHSD11B1NOTUMDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |