Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 14/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2948759 | 0.80 | MAPK14 (0.80) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL2948085 | 0.80 | MAPK14 (0.64) | LMNAMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL13234495 | 0.78 | MAPK14 (0.64) | LMNAMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL13234492 | 0.76 | MAPK14 (0.76) | LMNAMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL13234498 | 0.75 | LMNA (1.00) | LMNAMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5571951 | 0.75 | MAPK14 (0.69) | LMNAMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL18407354 | 0.75 | MAPK14 (0.81) | LMNAMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2083268 | 0.74 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL668606 | 0.74 | MAPK14 (1.00) | LMNAMAPK14MAPK11 | |
| SCHEMBL3296515 | 0.73 | MAPK14 (0.78) | MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761520-A1 | KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-03-14 | — | — | EP | disclosed |
| WO-2006009741-A1 | KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2006-01-26 | — | — | WO | disclosed |