Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 19/20 | 0.69 |
| ▸ | AKT2 | P31751 | 6/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.67 |
| ▸ | HRH2 | P25021 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12759248 | 0.86 | AKT1 (0.68) | AKT1AKT2KCNH2HRH2ADRA1A | |
| SCHEMBL1501750 | 0.85 | AKT1 (0.69) | AKT1AKT2KCNH2 | |
| SCHEMBL1501581 | 0.85 | AKT1 (0.75) | AKT1AKT2KCNH2HRH2ADRA1A | |
| SCHEMBL1501595 | 0.83 | AKT1 (0.71) | AKT1AKT2KCNH2HRH2ADRA1A | |
| SCHEMBL1501751 | 0.83 | AKT1 (0.65) | AKT1AKT2KCNH2HRH2ADRA1A | |
| SCHEMBL1501697 | 0.82 | AKT1 (0.64) | AKT1AKT2KCNH2HRH2ADRA1A | |
| SCHEMBL13405601 | 0.81 | AKT1 (0.63) | AKT1AKT2KCNH2HRH2ADRA1A | |
| SCHEMBL1502194 | 0.81 | KCNH2 (0.69) | AKT1AKT2KCNH2HRH2ADRA1A | |
| SCHEMBL1501610 | 0.81 | AKT1 (0.77) | AKT1AKT2KCNH2HRH2ADRA1A | |
| SCHEMBL5499353 | 0.81 | KCNH2 (0.74) | AKT1AKT2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1827436-A2 | INHIBITORS OF AKT ACTIVITY | Merck & Co., Inc. (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006065601-A2 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2006-06-22 | — | — | WO | claimed |