Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 5/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.52 |
| ▸ | FLT1 | P17948 | 4/20 | 0.52 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.52 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.52 |
| ▸ | FLT4 | P35916 | 4/20 | 0.52 |
| ▸ | KDR | P35968 | 4/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.50 |
| ▸ | EGFR | P00533 | 3/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.35 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5493929 | 0.80 | ENPP1 (0.64) | FGFR4FGFR1FLT1FGFR2FGFR3 | |
| SCHEMBL6000263 | 0.78 | EGFR (0.46) | FGFR4FGFR1FLT1KDREGFR | |
| SCHEMBL30000483 | 0.78 | ENPP1 (0.59) | FGFR4PDGFRBEGFRENPP1PDGFRA | |
| SCHEMBL241727 | 0.77 | EGFR (0.58) | FGFR4PDGFRBEGFRPDGFRAKDM4E | |
| SCHEMBL30001048 | 0.77 | EGFR (0.45) | FGFR4PDGFRBEGFRENPP1PDGFRA | |
| SCHEMBL5682691 | 0.77 | ENPP1 (0.48) | FGFR4PDGFRBEGFRENPP1PDGFRA | |
| SCHEMBL30000368 | 0.77 | EGFR (0.45) | FGFR4PDGFRBEGFRENPP1PDGFRA | |
| SCHEMBL30001229 | 0.77 | EGFR (0.45) | FGFR4PDGFRBEGFRENPP1PDGFRA | |
| SCHEMBL30864339 | 0.77 | ENPP1 (0.48) | FGFR4PDGFRBEGFRENPP1PDGFRA | |
| SCHEMBL5678927 | 0.77 | ENPP1 (0.48) | FGFR4PDGFRBEGFRENPP1PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262201-B1 | For the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals | ASTRAZENECA AB (SE) | 2007-08-28 | — | — | US | disclosed |
| EP-1005470-B1 | OXINDOLYLQUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2007-08-01 | — | — | EP | disclosed |
| EP-1119567-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-05-04 | — | — | EP | disclosed |
| US-6294532-B1 | TREATMENT OF A NUMBER OF DISEASE STATES INCLUDING CANCER AND RHEUMATOID ARTHRITIS. | ZENECA LIMITED (GB) | 2001-09-25 | — | — | US | disclosed |
| EP-1119567-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| EP-1005470-A1 | OXINDOLYLQUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 2000-06-07 | — | — | EP | disclosed |
| WO-2000021955-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-04-20 | — | — | WO | disclosed |
| WO-1999010349-A1 | OXINDOLYLQUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 1999-03-04 | — | — | WO | disclosed |