Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 7/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8277147 | 0.90 | GAA (0.57) | GAAALDH1A1SMN1; SMN2HIF1AMEN1 | |
| SCHEMBL26603400 | 0.89 | GAA (0.59) | GAAALDH1A1HPGDSMN1; SMN2NPSR1 | |
| SCHEMBL26603310 | 0.89 | HIF1A (0.73) | GAAALDH1A1HPGDSMN1; SMN2NPSR1 | |
| SCHEMBL30626166 | 0.89 | HIF1A (0.73) | GAAALDH1A1HPGDSMN1; SMN2NPSR1 | |
| SCHEMBL30709101 | 0.88 | GAA (0.59) | GAAALDH1A1HPGDSMN1; SMN2NPSR1 | |
| SCHEMBL26603470 | 0.88 | GAA (0.59) | GAAALDH1A1HPGDSMN1; SMN2NPSR1 | |
| SCHEMBL30709096 | 0.87 | GAA (0.57) | GAAALDH1A1HPGDSMN1; SMN2NPSR1 | |
| SCHEMBL26603583 | 0.87 | GAA (0.57) | GAAALDH1A1HPGDSMN1; SMN2NPSR1 | |
| SCHEMBL26603263 | 0.86 | HIF1A (0.67) | GAAALDH1A1HPGDSMN1; SMN2NPSR1 | |
| SCHEMBL26603432 | 0.86 | GAA (0.56) | GAAALDH1A1HPGDSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776106-A1 | HETEROCYCLIC DERIVATIVES FOR MODULATION OF CALCIUM CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2007-04-25 | — | — | EP | disclosed |
| WO-2006010008-A1 | HETEROCYCLIC DERIVATIVES FOR MODULATION OF CALCIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-01-26 | — | — | WO | disclosed |