Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 12/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | STAT1 | P42224 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5501667 | 0.90 | GAA (0.69) | GAAHIF1AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL1156495 | 0.82 | TDP1 (0.64) | GAAHIF1AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL26603400 | 0.80 | GAA (0.59) | GAAHIF1AALDH1A1USP2LMNA | |
| SCHEMBL30626166 | 0.80 | HIF1A (0.73) | GAAHIF1AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL26603310 | 0.80 | HIF1A (0.73) | GAAHIF1AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL26603470 | 0.79 | GAA (0.59) | GAAHIF1AALDH1A1USP2LMNA | |
| SCHEMBL30709101 | 0.79 | GAA (0.59) | GAAHIF1AALDH1A1USP2LMNA | |
| SCHEMBL1158781 | 0.78 | HPGD (0.51) | GAAALDH1A1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL26603583 | 0.78 | GAA (0.57) | GAAHIF1AALDH1A1SMN1; SMN2 | |
| SCHEMBL30709096 | 0.78 | GAA (0.57) | GAAHIF1AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006010008-A1 | HETEROCYCLIC DERIVATIVES FOR MODULATION OF CALCIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-01-26 | — | — | WO | disclosed |