Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 13/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.54 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4123911 | 1.00 | PTGDR2 (0.56) | PTGDR2NPSR1GPR55LMNASMN1; SMN2 | |
| SCHEMBL4123914 | 1.00 | PTGDR2 (0.56) | PTGDR2NPSR1GPR55LMNASMN1; SMN2 | |
| SCHEMBL4124990 | 0.94 | LMNA (0.56) | PTGDR2NPSR1GPR55LMNASMN1; SMN2 | |
| SCHEMBL6282494 | 0.94 | LMNA (0.56) | PTGDR2NPSR1GPR55LMNASMN1; SMN2 | |
| SCHEMBL4124993 | 0.94 | LMNA (0.56) | PTGDR2NPSR1GPR55LMNASMN1; SMN2 | |
| SCHEMBL4132877 | 0.89 | PTGDR2 (0.58) | PTGDR2NPSR1GPR55LMNASMN1; SMN2 | |
| SCHEMBL4132875 | 0.89 | PTGDR2 (0.58) | PTGDR2NPSR1GPR55LMNASMN1; SMN2 | |
| SCHEMBL4138016 | 0.84 | PTGDR2 (0.60) | PTGDR2NPSR1GPR55LMNASMN1; SMN2 | |
| SCHEMBL4138012 | 0.84 | PTGDR2 (0.60) | PTGDR2NPSR1GPR55LMNASMN1; SMN2 | |
| SCHEMBL6278727 | 0.83 | PTGDR2 (0.59) | PTGDR2NPSR1LMNASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740547-A1 | PGD2 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005100321-A1 | PGD2 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-10-27 | — | — | WO | disclosed |