Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 4/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 4/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL551046 | 1.00 | HCRTR2 (0.42) | HCRTR2HCRTR1PIM1PIK3CAHSD11B1 | |
| SCHEMBL2700944 | 1.00 | HCRTR2 (0.42) | HCRTR2HCRTR1PIM1PIK3CAHSD11B1 | |
| SCHEMBL2699847 | 0.90 | HSD11B1 (0.45) | HCRTR2HCRTR1PIK3CAHSD11B1CNR2 | |
| SCHEMBL551432 | 0.90 | HSD11B1 (0.45) | HCRTR2HCRTR1PIK3CAHSD11B1CNR2 | |
| SCHEMBL554434 | 0.90 | HSD11B1 (0.45) | HCRTR2HCRTR1PIK3CAHSD11B1CNR2 | |
| SCHEMBL2700334 | 0.90 | PIK3CA (0.39) | HCRTR2HCRTR1PIK3CAHSD11B1EGLN1 | |
| SCHEMBL550972 | 0.90 | PIK3CA (0.39) | HCRTR2HCRTR1PIK3CAHSD11B1EGLN1 | |
| SCHEMBL550971 | 0.90 | PIK3CA (0.39) | HCRTR2HCRTR1PIK3CAHSD11B1EGLN1 | |
| SCHEMBL2700330 | 0.90 | PIK3CA (0.39) | HCRTR2HCRTR1PIK3CAHSD11B1EGLN1 | |
| SCHEMBL550906 | 0.90 | PIK3CA (0.39) | HCRTR2HCRTR1PIK3CAHSD11B1EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |