Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 6/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30250859 | 0.83 | ADORA2A (0.58) | ADORA1ADORA2AATMHPGDADORA2B | |
| SCHEMBL23998166 | 0.83 | ADORA2A (0.58) | ADORA1ADORA2AATMHPGDADORA2B | |
| SCHEMBL5501933 | 0.82 | ADORA1 (0.64) | ADORA1ADORA2AHPGDKDM4EADORA2B | |
| SCHEMBL10360609 | 0.81 | ATM (0.44) | ADORA1ADORA2AATMHPGDADORA2B | |
| SCHEMBL8914694 | 0.81 | ADORA1 (0.54) | ADORA1ADORA2AHPGDALDH1A1KDM4E | |
| SCHEMBL2645516 | 0.80 | ADORA1 (0.58) | ADORA1ADORA2AHPGDALDH1A1KDM4E | |
| SCHEMBL18866750 | 0.78 | ADORA2A (0.52) | ADORA1ADORA2AHPGDALDH1A1ADORA2B | |
| SCHEMBL5501424 | 0.76 | LMNA (0.54) | ATMHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL8130126 | 0.74 | GAA (0.65) | HPGDKDM4EKMT2ARAB9AGAA | |
| SCHEMBL14809869 | 0.74 | ADORA2A (0.58) | ADORA1ADORA2AKDM4EADORA2BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9067928-B2 | Compounds and methods of use | ABBVIE INC. (US) | 2015-06-30 | — | — | US | disclosed |
| US-8518970-B2 | Compounds and methods of use | ABBVIE INC. (US) | 2013-08-27 | — | — | US | disclosed |