Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 8/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2699722 | 1.00 | HSD11B1 (0.35) | HSD11B1FFAR4CHEK1KDM4EMEN1 | |
| SCHEMBL550209 | 1.00 | HSD11B1 (0.35) | HSD11B1FFAR4CHEK1KDM4EMEN1 | |
| SCHEMBL549674 | 1.00 | HSD11B1 (0.35) | HSD11B1FFAR4CHEK1KDM4EMEN1 | |
| SCHEMBL17082093 | 1.00 | HSD11B1 (0.35) | HSD11B1FFAR4CHEK1KDM4EMEN1 | |
| SCHEMBL2699717 | 1.00 | HSD11B1 (0.35) | HSD11B1FFAR4CHEK1KDM4EMEN1 | |
| SCHEMBL4572368 | 1.00 | HSD11B1 (0.35) | HSD11B1FFAR4CHEK1KDM4EMEN1 | |
| SCHEMBL549673 | 1.00 | HSD11B1 (0.35) | HSD11B1FFAR4CHEK1KDM4EMEN1 | |
| SCHEMBL550123 | 0.88 | HSD11B1 (0.43) | HSD11B1FFAR4AR | |
| SCHEMBL2699603 | 0.88 | HSD11B1 (0.43) | HSD11B1FFAR4AR | |
| SCHEMBL2699601 | 0.88 | HSD11B1 (0.43) | HSD11B1FFAR4AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |