Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | PTGER4 | P35408 | 8/20 | 0.49 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.48 |
| ▸ | TMPRSS4 | Q9NRS4 | 3/20 | 0.46 |
| ▸ | P2RX1 | P51575 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | BCL2 | P10415 | 1/20 | 0.45 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.45 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.45 |
| ▸ | PHGDH | O43175 | 1/20 | 0.44 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.44 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4012461 | 0.86 | PTGER4 (0.64) | PTGER4PTGER2KDM4ELMNAHPGD | |
| SCHEMBL26097486 | 0.84 | P2RX1 (0.56) | CA1CA2PTGER4PTGER2TMPRSS4 | |
| SCHEMBL26097490 | 0.84 | P2RX1 (0.56) | CA1CA2PTGER4PTGER2TMPRSS4 | |
| SCHEMBL30100454 | 0.84 | P2RX1 (0.56) | CA1CA2PTGER4PTGER2TMPRSS4 | |
| SCHEMBL26095797 | 0.82 | HPGD (0.68) | CA1CA2PTGER4TMPRSS4P2RX1 | |
| SCHEMBL17329358 | 0.82 | HPGD (0.68) | CA1CA2PTGER4TMPRSS4P2RX1 | |
| SCHEMBL15889798 | 0.82 | HPGD (0.68) | CA1CA2PTGER4TMPRSS4P2RX1 | |
| SCHEMBL30100509 | 0.82 | HPGD (0.68) | CA1CA2PTGER4TMPRSS4P2RX1 | |
| SCHEMBL30100413 | 0.82 | HPGD (0.68) | CA1CA2PTGER4TMPRSS4P2RX1 | |
| SCHEMBL23675460 | 0.80 | P2RX1 (0.60) | PTGER4PTGER2P2RX1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740211-A2 | COMBINATIONS COMPRISING ALPHA-2-DELTA LIGANDS AND EP4 RECEPTOR ANTAGONISTS | Pfizer Products Incorporated (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005102389-A2 | COMBINATIONS COMPRISING ALPHA-2-DELTA LIGANDS AND EP4 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2005-11-03 | — | — | WO | disclosed |