Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | PTGDR2 | Q9Y5Y4 | 12/20 | 0.59 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4132598 | 1.00 | LMNA (0.59) | LMNANPSR1HTTPOLBMAPT | |
| SCHEMBL4132600 | 1.00 | LMNA (0.59) | LMNANPSR1HTTPOLBMAPT | |
| SCHEMBL13776124 | 0.90 | PTGDR2 (0.73) | LMNANPSR1HTTPOLBMAPT | |
| SCHEMBL4124398 | 0.88 | PTGDR2 (0.52) | LMNANPSR1HTTPOLBMAPT | |
| SCHEMBL4124396 | 0.88 | PTGDR2 (0.52) | LMNANPSR1HTTPOLBMAPT | |
| Propionamide SCHEMBL4129719 | 0.86 | PTGDR2 (0.49) | LMNANPSR1HTTPOLBMAPT | |
| Propionamide SCHEMBL4129716 | 0.86 | PTGDR2 (0.49) | LMNANPSR1HTTPOLBMAPT | |
| SCHEMBL4129711 | 0.85 | PTGDR2 (0.80) | LMNANPSR1HTTPOLBMAPT | |
| SCHEMBL4129709 | 0.85 | PTGDR2 (0.80) | LMNANPSR1HTTPOLBMAPT | |
| SCHEMBL6282494 | 0.85 | LMNA (0.56) | LMNANPSR1HTTPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740547-A1 | PGD2 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005100321-A1 | PGD2 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-10-27 | — | — | WO | disclosed |