SCHEMBL5502491

SCHEMBL5502491

CC1CC(C)CN(CCCN2[C]N(CCCN3CCCCC3C)CC2)C1

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CXCR4 P61073 6/20 0.39
CHRM2 P08172 1/20 0.36
CHRM1 P11229 1/20 0.36
USP2 O75604 1/20 0.36
TSHR P16473 1/20 0.36
SCN1A P35498 1/20 0.35
SCN2A Q99250 1/20 0.35
SCN3A Q9NY46 1/20 0.35
ACHE P22303 1/20 0.35
HRH3 Q9Y5N1 2/20 0.34
MAOB P27338 2/20 0.34
HRH2 P25021 1/20 0.34
HRH1 P35367 1/20 0.34
MAOA P21397 1/20 0.33
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5502044 0.96 HRH3 (0.35) CXCR4USP2TSHRHRH3
SCHEMBL5501715 0.92 HRH3 (0.34) CXCR4HRH3
SCHEMBL5502752 0.85 CXCR4 (0.47) CXCR4CHRM2CHRM1SCN1ASCN2A
SCHEMBL5506775 0.85 CXCR4 (0.47) CXCR4CHRM2CHRM1SCN1ASCN2A
SCHEMBL5505202 0.85 HRH3 (0.39) CHRM2CHRM1HRH3MAOBHRH2
SCHEMBL5502494 0.85 CXCR4 (0.42) CXCR4CHRM2CHRM1USP2TSHR
SCHEMBL5507033 0.84 HRH3 (0.42) CXCR4SCN1ASCN2ASCN3AACHE
SCHEMBL5504002 0.84 HRH3 (0.39) USP2TSHRHRH3MAOB
SCHEMBL5501569 0.83 CXCR4 (0.41) CXCR4CHRM2CHRM1SCN1ASCN2A
SCHEMBL5508093 0.83 USP2 (0.34) USP2TSHRHRH3MAOBHRH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1847530-A1 DIAMINE DERIVATIVE KYOWA HAKKO KOGYO CO., LTD. (JP) 2007-10-24 EP disclosed