Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 17/20 | 0.42 |
| ▸ | CTSD | P07339 | 7/20 | 0.42 |
| ▸ | MMP3 | P08254 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4472723 | 0.83 | BACE1 (0.55) | BACE1CTSDKMT2ABACE2 | |
| SCHEMBL5506166 | 0.81 | BACE1 (0.47) | BACE1CTSDBACE2 | |
| SCHEMBL4478905 | 0.81 | BACE1 (0.46) | BACE1CTSDKMT2ABACE2 | |
| SCHEMBL4495562 | 0.80 | BACE1 (0.68) | BACE1CTSDBACE2 | |
| SCHEMBL4478091 | 0.77 | KDM4E (0.45) | BACE1CTSDKMT2ABACE2 | |
| SCHEMBL4490828 | 0.76 | BACE1 (0.69) | BACE1 | |
| SCHEMBL4476915 | 0.76 | BACE1 (0.68) | BACE1CTSDBACE2 | |
| SCHEMBL4472988 | 0.75 | BACE1 (0.62) | BACE1CTSD | |
| SCHEMBL4468046 | 0.74 | BACE1 (0.51) | BACE1CTSDBACE2 | |
| SCHEMBL4474607 | 0.74 | BACE1 (0.68) | BACE1CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848692-A1 | AZOLYLACYLGUANIDINES AS ß-SECRETASE INHIBITORS | Wyeth (US) | 2007-10-31 | — | — | EP | claimed |
| WO-2006088711-A1 | AZOLYLACYLGUANIDINES AS β-SECRETASE INHIBITORS | WYETH (US) | 2006-08-24 | — | — | WO | claimed |
| EP-1848692-A1 | AZOLYLACYLGUANIDINES AS ß-SECRETASE INHIBITORS | Wyeth (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006088711-A1 | AZOLYLACYLGUANIDINES AS β-SECRETASE INHIBITORS | WYETH (US) | 2006-08-24 | — | — | WO | disclosed |