Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 15/20 | 0.47 |
| ▸ | CTSD | P07339 | 9/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.44 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | F7 | P08709 | 2/20 | 0.38 |
| ▸ | F3 | P13726 | 2/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4472723 | 0.84 | BACE1 (0.55) | BACE1CTSDBACE2KDM4EALDH1A1 | |
| SCHEMBL5502569 | 0.83 | BACE1 (0.47) | BACE1CTSDBACE2KDM4EALDH1A1 | |
| SCHEMBL4476915 | 0.83 | BACE1 (0.68) | BACE1CTSDBACE2 | |
| SCHEMBL5502499 | 0.81 | BACE1 (0.42) | BACE1CTSDBACE2 | |
| SCHEMBL4494111 | 0.80 | BACE1 (0.70) | BACE1CTSDBACE2 | |
| SCHEMBL4490828 | 0.79 | BACE1 (0.69) | BACE1HPGD | |
| SCHEMBL4468046 | 0.79 | BACE1 (0.51) | BACE1CTSDBACE2 | |
| SCHEMBL4472988 | 0.78 | BACE1 (0.62) | BACE1CTSD | |
| SCHEMBL4478091 | 0.75 | KDM4E (0.45) | BACE1CTSDBACE2KDM4EALDH1A1 | |
| SCHEMBL4491289 | 0.75 | BACE1 (0.65) | BACE1CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848692-A1 | AZOLYLACYLGUANIDINES AS ß-SECRETASE INHIBITORS | Wyeth (US) | 2007-10-31 | — | — | EP | claimed |
| WO-2006088711-A1 | AZOLYLACYLGUANIDINES AS β-SECRETASE INHIBITORS | WYETH (US) | 2006-08-24 | — | — | WO | claimed |
| EP-1848692-A1 | AZOLYLACYLGUANIDINES AS ß-SECRETASE INHIBITORS | Wyeth (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006088711-A1 | AZOLYLACYLGUANIDINES AS β-SECRETASE INHIBITORS | WYETH (US) | 2006-08-24 | — | — | WO | disclosed |