Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 9/20 | 0.45 |
| ▸ | GGPS1 | O95749 | 6/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | PPARD | Q03181 | 2/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.41 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.41 |
| ▸ | TLR2 | O60603 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL945896 | 0.98 | FDPS (0.46) | FDPSGGPS1AKR1B1CES2GPR84 | |
| SCHEMBL6230681 | 0.95 | FDPS (0.45) | FDPSGGPS1AKR1B1CES2GPR84 | |
| SCHEMBL6056814 | 0.95 | FDPS (0.48) | FDPSGGPS1CES2GPR84PPARG | |
| SCHEMBL6056806 | 0.95 | FDPS (0.48) | FDPSGGPS1CES2GPR84PPARG | |
| SCHEMBL1990820 | 0.95 | FDPS (0.48) | FDPSGGPS1CES2GPR84PPARG | |
| SCHEMBL1916481 | 0.95 | FDPS (0.48) | FDPSGGPS1CES2GPR84PPARG | |
| SCHEMBL7172854 | 0.95 | FDPS (0.48) | FDPSGGPS1CES2GPR84PPARG | |
| SCHEMBL6056892 | 0.95 | FDPS (0.48) | FDPSGGPS1CES2GPR84PPARG | |
| SCHEMBL6056832 | 0.95 | FDPS (0.48) | FDPSGGPS1CES2GPR84PPARG | |
| SCHEMBL6056853 | 0.95 | FDPS (0.48) | FDPSGGPS1CES2GPR84PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819681-A1 | 7-(2H-PYRAZOL-3-YL)-3,5-DIHYDROXY-HEPTANOIC ACID DERIVATIVES AS HMG CO-A REDUCTASE INHIBITORS FOR THE TREATMENT OF LIPIDEMIA | Warner-Lambert Company LLC (US) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006056845-A1 | 7-(2H-PYRAZOL-3-YL)-3, 5-DIHYROXY-HEPTANOIC ACID DERIVATIVES AS HMG CO-A REDUCTASE INHIBITORS FOR THE TREATMENT OF LIPIDEMIA | WARNER-LAMBERT COMPANY LLC (US) | 2006-06-01 | — | — | WO | disclosed |
| EP-1521743-A1 | HMG-COA REDUCTASE INHIBITORS | Ranbaxy Laboratories Limited (IN) | 2005-04-13 | — | — | EP | disclosed |
| WO-2004005250-A1 | HMG-COA REDUCTASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2004-01-15 | — | — | WO | disclosed |