Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5507590 | 0.84 | IRAK4 (0.41) | IRAK4KCNH2 | |
| SCHEMBL3692448 | 0.84 | KDM4E (0.46) | IRAK4KDM4EKCNH2HTR1AADRA1D | |
| SCHEMBL3692451 | 0.84 | KDM4E (0.46) | IRAK4KDM4EKCNH2HTR1AADRA1D | |
| SCHEMBL5509173 | 0.84 | MTNR1B (0.41) | IRAK4HTR1ANCF1 | |
| SCHEMBL5503330 | 0.83 | MTNR1B (0.43) | IRAK4KDM4E | |
| SCHEMBL5504441 | 0.82 | KCNH2 (0.41) | IRAK4KCNH2HTR1AMETLMNA | |
| SCHEMBL4512730 | 0.81 | KCNH2 (0.37) | KCNH2 | |
| SCHEMBL5506070 | 0.76 | MTNR1B (0.52) | IRAK4 | |
| SCHEMBL591215 | 0.73 | KDM4E (0.44) | KDM4EKCNH2HTR1AADRA1DADRA1A | |
| SCHEMBL591216 | 0.73 | KDM4E (0.44) | KDM4EKCNH2HTR1AADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799676-A2 | NEW BICYCLIC ANTIBIOTICS | Actelion Pharmaceuticals Ltd. (CH) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006032466-A2 | NEW BICYCLIC ANTIBIOTICS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-30 | — | — | WO | disclosed |