Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Phenylalanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.48 |
| ▸ | ALPI | P09923 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | XIAP | P98170 | 1/20 | 0.48 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | ANPEP | P15144 | 2/20 | 0.46 |
| ▸ | RNPEP | Q9H4A4 | 2/20 | 0.46 |
| ▸ | DNPEP | Q9ULA0 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | GSR | P00390 | 1/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | FNTA | P49354 | 3/20 | 0.40 |
| ▸ | FNTB | P49356 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Phenylalanine SCHEMBL27473663 | 0.94 | ALPI (0.44) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Dl-Phenylalanine SCHEMBL22207662 | 0.92 | SLC7A5 (0.56) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Phenylalanine SCHEMBL8674476 | 0.92 | SLC7A5 (0.56) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Phenylalanine SCHEMBL9295527 | 0.91 | SLC7A5 (0.55) | ALPIPKMPTGS1XIAPSLC7A5 | |
| D-Phenylalanine SCHEMBL6450960 | 0.91 | SLC7A5 (0.58) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Dl-Phenylalanine SCHEMBL3691104 | 0.91 | SLC7A5 (0.58) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Phenylalanine SCHEMBL907512 | 0.91 | SLC7A5 (0.58) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Phenylalanine SCHEMBL723829 | 0.91 | SLC7A5 (0.58) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Phenylalanine SCHEMBL9541187 | 0.91 | SLC7A5 (0.58) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Phenylalanine SCHEMBL15323398 | 0.91 | SLC7A5 (0.58) | ALPIPKMPTGS1XIAPSLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1811979-A2 | MICROCAPSULES COMPRISING A METHYLXANTHINE AND A CORTICOSTEROID | Sigmoid Biotechnologies Limited (IE) | 2007-08-01 | — | — | EP | disclosed |
| EP-1802287-A2 | MINICAPSULE FORMULATIONS | Sigmoid Biotechnologies Limited (IE) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006035418-A2 | MICROCAPSULES COMPRISING A METHYLXANTHINE AND A CORTICOSTEROID | SIGMOID BIOTECHNOLOGIES LIMITED (IE) | 2006-04-06 | — | — | WO | disclosed |
| WO-2006035416-A2 | MINICAPSULE FORMULATIONS | SIGMOID BIOTECHNOLOGIES LIMITED (IE) | 2006-04-06 | — | — | WO | disclosed |