Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 4/20 | 0.39 |
| ▸ | HTR6 | P50406 | 3/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2784464 | 0.96 | DRD2 (0.52) | DRD2HTR2AHRH1KDM2BDRD3 | |
| SCHEMBL2783663 | 0.90 | DRD2 (0.54) | DRD2HTR2AHRH1KDM2BDRD3 | |
| SCHEMBL2780967 | 0.85 | DRD2 (0.70) | DRD2HTR2ADRD3HTR6ADRA1D | |
| SCHEMBL2781597 | 0.83 | DRD2 (0.44) | DRD2HTR2AHRH1DRD3HTR6 | |
| SCHEMBL2783446 | 0.81 | DRD2 (0.43) | DRD2HTR2AHRH1DRD3DRD4 | |
| SCHEMBL2783238 | 0.79 | DRD2 (0.56) | DRD2HTR2AADRA1DADRA1AADRA1B | |
| SCHEMBL2782910 | 0.78 | DRD2 (0.55) | DRD2HTR2ADRD3HTR6ADRA1D | |
| SCHEMBL2782534 | 0.78 | DRD2 (0.55) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| SCHEMBL2783216 | 0.78 | DRD2 (0.49) | DRD2HTR2AHRH1DRD3ADRA1D | |
| SCHEMBL5505894 | 0.78 | DRD2 (0.43) | DRD2HTR2AHRH1KDM2BDRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773772-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-18 | — | — | EP | disclosed |
| WO-2005121087-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | disclosed |