Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11354188 | 0.95 | SMN1; SMN2 (0.59) | SMN1; SMN2KMT2ACYP1A2TSHRCYP2C19 | |
| SCHEMBL11417022 | 0.84 | KMT2A (0.48) | SMN1; SMN2KMT2ACYP1A2TSHRCYP2C19 | |
| SCHEMBL11340948 | 0.82 | SMN1; SMN2 (0.52) | SMN1; SMN2KMT2ACYP1A2TSHRCYP2C19 | |
| SCHEMBL11342790 | 0.82 | KMT2A (0.53) | SMN1; SMN2KMT2ACYP1A2TSHRCYP2C19 | |
| SCHEMBL11596058 | 0.81 | SMN1; SMN2 (0.59) | SMN1; SMN2KMT2ACYP1A2TSHRCYP2C19 | |
| SCHEMBL11596686 | 0.81 | KMT2A (0.79) | SMN1; SMN2KMT2ACYP1A2TSHRCYP2C19 | |
| SCHEMBL11526842 | 0.80 | SMN1; SMN2 (0.58) | SMN1; SMN2KMT2ACYP1A2TSHRCYP2C19 | |
| SCHEMBL11595412 | 0.78 | SMN1; SMN2 (0.62) | SMN1; SMN2KMT2ACYP1A2TSHRCYP2C19 | |
| SCHEMBL11597512 | 0.78 | SMN1; SMN2 (0.74) | SMN1; SMN2KMT2ACYP1A2TSHRCYP2C19 | |
| SCHEMBL11597649 | 0.78 | SMN1; SMN2 (1.00) | SMN1; SMN2KMT2ACYP1A2TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844011-A1 | 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | Aventis Pharmaceuticals Inc. (US) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006081343-A1 | 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | AVENTIS PHARMACEUTICALS INC. (US) | 2006-08-03 | — | — | WO | disclosed |