Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 6/20 | 0.47 |
| ▸ | CA9 | Q16790 | 6/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11354188 | 0.87 | SMN1; SMN2 (0.59) | SMN1; SMN2KMT2ACYP1A2TSHRCYP2C19 | |
| SCHEMBL11347734 | 0.85 | GSTO1 (0.53) | SMN1; SMN2KMT2ACYP1A2TSHRCYP2C19 | |
| SCHEMBL11596058 | 0.83 | SMN1; SMN2 (0.59) | SMN1; SMN2KMT2ACYP1A2TSHRCYP2C19 | |
| SCHEMBL5504045 | 0.82 | SMN1; SMN2 (0.63) | SMN1; SMN2KMT2ACYP1A2TSHRCYP2C19 | |
| SCHEMBL11526842 | 0.82 | SMN1; SMN2 (0.58) | SMN1; SMN2KMT2ACYP1A2TSHRCYP2C19 | |
| SCHEMBL11343260 | 0.80 | CA1 (0.54) | CA12CA9CA1CA2 | |
| SCHEMBL11343142 | 0.80 | GSTO1 (0.53) | SMN1; SMN2KMT2ACYP1A2TSHRCYP2C19 | |
| SCHEMBL11348810 | 0.80 | GSTO1 (0.44) | SMN1; SMN2KMT2ACYP1A2TSHRCYP2C19 | |
| SCHEMBL11596686 | 0.80 | KMT2A (0.79) | SMN1; SMN2KMT2ACYP1A2TSHRCYP2C19 | |
| SCHEMBL11595412 | 0.80 | SMN1; SMN2 (0.62) | SMN1; SMN2KMT2ACYP1A2TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0001051-B1 | DERIVATIVES OF BENZENESULFONAMIDE, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-02-11 | — | — | EP | claimed |
| US-4235918-A | SALIDIURETICS, TREATMENT OF HYPERTONIC CONDITIONS | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-11-25 | — | — | US | claimed |
| EP-0001051-B1 | DERIVATIVES OF BENZENESULFONAMIDE, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-02-11 | — | — | EP | disclosed |
| US-4235918-A | SALIDIURETICS, TREATMENT OF HYPERTONIC CONDITIONS | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-11-25 | — | — | US | disclosed |