Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.54 |
| ▸ | DRD3 | P35462 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5502094 | 0.90 | DRD2 (0.45) | DRD2DRD3HTR1AKDM2BADRA1D | |
| SCHEMBL5505609 | 0.85 | DRD2 (0.52) | DRD2DRD3HTR1AKDM2BTSHR | |
| SCHEMBL2784652 | 0.82 | DRD2 (0.57) | DRD2DRD3HTR1A | |
| SCHEMBL2783380 | 0.82 | DRD2 (0.57) | DRD2DRD3HTR1A | |
| SCHEMBL2783658 | 0.81 | DRD2 (0.63) | DRD2DRD3HTR1A | |
| SCHEMBL2783754 | 0.81 | DRD2 (0.56) | DRD2DRD3HTR1AADRA1DADRA1A | |
| SCHEMBL2782009 | 0.81 | DRD2 (0.56) | DRD2DRD3HTR1ATSHR | |
| SCHEMBL2783923 | 0.79 | KDM2B (0.48) | DRD2DRD3HTR1AKDM2BTSHR | |
| SCHEMBL2781774 | 0.79 | KDM2B (0.48) | DRD2DRD3HTR1AKDM2BTSHR | |
| SCHEMBL2782967 | 0.78 | DRD2 (0.48) | DRD2DRD3HTR1AKDM2BTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773772-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-18 | — | — | EP | disclosed |
| WO-2005121087-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | disclosed |