Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.50 |
| ▸ | PSEN1 | P49768 | 10/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 10/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 10/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 10/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 10/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 10/20 | 0.46 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2332910 | 0.82 | ADAMTS5 (0.51) | CNR2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2332915 | 0.82 | ADAMTS5 (0.51) | CNR2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5512141 | 0.80 | TDP1 (0.61) | CNR2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8911648 | 0.79 | CNR2 (0.67) | CNR2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2336639 | 0.78 | CNR2 (0.46) | CNR2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2336636 | 0.78 | CNR2 (0.46) | CNR2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2335090 | 0.76 | MEN1 (0.44) | CNR2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2338732 | 0.76 | CA1 (0.50) | CNR2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27994291 | 0.75 | CNR2 (0.45) | CNR2SERPINE1CA12CA1CA9 | |
| SCHEMBL2336036 | 0.75 | PSEN1 (0.58) | CNR2PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549306-A4 | SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH CORP (US) | 2007-06-06 | — | — | EP | claimed |
| EP-1549306-A1 | SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | Wyeth (US) | 2005-07-06 | — | — | EP | claimed |
| WO-2003103660-A1 | SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH (US) | 2003-12-18 | — | — | WO | claimed |