SCHEMBL5504443

SCHEMBL5504443

CC(C)Oc1cncc(C2NCC23CC3)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 3/20 0.37
CHRNA4 P43681 3/20 0.37
CHRNB4 P30926 2/20 0.37
CHRNA3 P32297 2/20 0.37
CHRNB3 Q05901 2/20 0.37
CHRNA6 Q15825 2/20 0.37
CHRNA7 P36544 1/20 0.37
CYP11B1 P15538 2/20 0.32
CYP11B2 P19099 2/20 0.32
BRD4 O60885 1/20 0.32
CREBBP Q92793 1/20 0.32
PIK3CD O00329 1/20 0.31
PIP5K1C O60331 1/20 0.31
PIK3CA P42336 1/20 0.31
PIK3CB P42338 1/20 0.31
PI4KA P42356 1/20 0.31
PIK3CG P48736 1/20 0.31
PI4KB Q9UBF8 1/20 0.31
GAA P10253 1/20 0.30
CYP2C19 P33261 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5508372 0.84 CHRNB2 (0.38) CHRNB2CHRNA4CHRNB4CHRNA3CHRNB3
SCHEMBL5507467 0.77 CHRNB2 (0.38) CHRNB2CHRNA4CHRNB4CHRNA3CHRNB3
SCHEMBL5503087 0.77 CHRNB2 (0.40) CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL3464520 0.75 CHRNB2 (0.42) CHRNB2CHRNA4CHRNB4CHRNA3CHRNB3
SCHEMBL5502458 0.75 CHRNB2 (0.40) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7
SCHEMBL5507734 0.73 CHRNB2 (0.34) CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL3464499 0.71 CHRNB2 (0.39) CHRNB2CHRNA4CHRNB4CHRNA3CHRNB3
SCHEMBL5509082 0.70 CHRNB2 (0.36) CHRNB2CHRNA4CHRNB4CHRNA3CHRNB3
SCHEMBL5507522 0.70
SCHEMBL5506753 0.70 CHRNB2 (0.38) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1802601-A1 AZASPIROALKENE AND AZAPIROALKANE COMPOUNDS WITH NICOTINIC CHOLINERGIC RECEPTOR ACTIVITY Targacept, Inc. (US) 2007-07-04 EP disclosed
WO-2006034089-A1 AZASPIROALKENE AND AZASPIROALKANE COMPOUNDS WITH NICOTINIC CHOLINERGIC RECEPTOR ACTIVITY TARGACEPT, INC. (US) 2006-03-30 WO disclosed