Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 9/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 2/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7412709 | 0.91 | KMT2A (0.58) | KMT2AMEN1PKMMAPTALDH1A1 | |
| SCHEMBL4770411 | 0.85 | KDM4E (0.50) | KMT2AMEN1PKMMAPTALDH1A1 | |
| SCHEMBL15445432 | 0.85 | KMT2A (0.64) | KMT2AMEN1PKMMAPTALDH1A1 | |
| SCHEMBL29366579 | 0.84 | KMT2A (0.63) | KMT2AMEN1PKMMAPTALDH1A1 | |
| SCHEMBL393627 | 0.84 | KMT2A (0.63) | KMT2AMEN1PKMMAPTALDH1A1 | |
| SCHEMBL437783 | 0.83 | KMT2A (0.67) | KMT2AMEN1PKMMAPTALDH1A1 | |
| SCHEMBL31312808 | 0.83 | KMT2A (0.62) | KMT2AMEN1PKMMAPTALDH1A1 | |
| SCHEMBL20494881 | 0.83 | KMT2A (0.62) | KMT2AMEN1PKMMAPTALDH1A1 | |
| SCHEMBL20495354 | 0.83 | KMT2A (0.62) | KMT2AMEN1PKMMAPTALDH1A1 | |
| SCHEMBL776014 | 0.83 | MEN1 (0.67) | KMT2AMEN1PKMMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1771443-A1 | QUINOLINE THIAZOLINONES WITH CDK1 ANTIPROLIFERATIVE ACTIVITY | F.HOFFMANN-LA ROCHE AG (CH) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006002828-A1 | QUINOLINE THIAZOLINONES WITH CDK1 ANTIPROLIFERATIVE ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2006-01-12 | — | — | WO | disclosed |